Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Focusing of Light in the Eye01:16

Focusing of Light in the Eye

4.7K
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
4.7K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

997
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
997

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Finite Element Modeling of Aqueous Outflow and Trabeculotomy in Glaucomatous Eyes With Resistive and Segmented Schlemm's Canal.

Lasers in surgery and medicine·2026
Same author

Impact of the loss of tenascin X on tissue architecture and wound healing of the murine corneal stroma.

The ocular surface·2026
Same author

A Systematic and Narrative Review of Safety and Complications in Minimally Invasive Glaucoma Surgery (MIGS) Between 2014-2024 [Letter].

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Influences of Temperature and Time on Habitat Use Patterns of a Semi-Aquatic Turtle.

Ecology and evolution·2025
Same author

Enhanced Riboflavin Stromal Delivery Using Microchannel-Assisted Iontophoresis for Corneal Crosslinking.

Translational vision science & technology·2025
Same author

3D Finite Element Modeling of Femtosecond Laser Trabeculotomy.

Lasers in surgery and medicine·2025

Related Experiment Video

Updated: Dec 10, 2025

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
05:46

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

Published on: September 20, 2024

679

Nonlinear optical crosslinking (NLO CXL) for correcting refractive errors.

Samantha Bradford1, Eric Mikula1, Tibor Juhasz1

  • 1Department of Ophthalmology and Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.

Experimental Eye Research
|August 27, 2020
PubMed
Summary

Femtosecond laser-activated riboflavin (Rf) offers a precise, safer alternative to UVA light for corneal crosslinking (CXL). This advanced method enables controlled stiffening and reshaping of the cornea for refractive error correction.

Keywords:
CorneaCrosslinkingFemtosecond laserNonlinear

More Related Videos

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.2K
Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

8.1K

Related Experiment Videos

Last Updated: Dec 10, 2025

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
05:46

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

Published on: September 20, 2024

679
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.2K
Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

8.1K

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Corneal Science

Background:

  • Corneal crosslinking (CXL) using Ultraviolet A (UVA) light and riboflavin (Rf) is established for treating corneal ectasia and keratoconus.
  • This technique is adapted for refractive error correction via topography-guided photorefractive intrastromal CXL (PiXL).

Purpose of the Study:

  • To review the application of femtosecond (FS) lasers for photoactivating Rf to perform controlled corneal CXL.
  • To highlight the advantages of FS laser-based NLO CXL over traditional UVA CXL for refractive correction.

Main Methods:

  • Utilizing femtosecond (FS) lasers to photoactivate riboflavin (Rf) for corneal crosslinking (CXL).
  • Implementing nonlinear optical crosslinking (NLO CXL) for precise treatment volume control within the focal laser spot.
  • Employing topographically guided patterns for refractive correction.

Main Results:

  • NLO CXL replicates UVA CXL effects with reduced cellular damage and shorter procedure times.
  • FS laser-based NLO CXL allows for precise placement and scanning of the treatment volume at any corneal depth.
  • Achieved mechanical stiffening and controlled changes in corneal shape for refractive correction.

Conclusions:

  • FS laser-mediated NLO CXL presents a faster, safer, and more precise method for corneal crosslinking.
  • This technology enables true topographically guided refractive correction by precisely controlling the CXL treatment volume.
  • NLO CXL holds significant potential for non-invasive treatment of refractive errors and ectatic corneal diseases.