New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer targeted therapy

Area of Science:

• Biochemistry
• Pharmacology
• Oncology

Background:

• Cancer survival rates have improved due to early detection and targeted therapies, but many cancers still have a five-year survival rate below five years.
• Developing novel anticancer drugs is crucial to combat complex cancers and further enhance patient survival rates.
• Natural sources like venom sacs and bacteria contain diverse biomolecules with potential therapeutic applications.

Purpose of the Study:

• To review identified molecular targets for anticancer effects of venom-based and bacteria-derived biomolecules.
• To explore the molecular mechanisms underlying the anticancer potential of these natural compounds.
• To guide the development of new targeted anticancer therapies.

Main Methods:

• Literature review of studies on venomous and bacterial biomolecules with anticancer properties.
• Identification and categorization of molecular targets, including ion channels, membrane non-receptor molecules, and integrins.
• Analysis of the mode of action for these biomolecules.

Main Results:

• Venomous and bacterial biomolecules target key cellular components involved in cancer progression.
• Identified targets include ion channels, membrane non-receptor molecules, and integrins.
• Understanding these targets is essential for leveraging their full therapeutic potential.

Conclusions:

• Venom and bacteria represent a rich source of novel anticancer drug candidates.
• Further research into their molecular targets will facilitate the development of effective targeted therapies.
• This review provides a foundation for future drug discovery and development in oncology.