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Pharmacokinetics of high-dose etoposide
E M Newman1, J H Doroshow, S J Forman
1Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010.
Clinical Pharmacology and Therapeutics
|May 1, 1988
Abstract:
The pharmacokinetics of etoposide at doses of 1 gm/m2 to 3 gm/m2 were studied in patients with hematologic malignancies. The noncompartmental systemic clearance, mean residence time, steady-state volume of distribution, and elimination half-life were independent of the dose of etoposide, whereas the AUC was proportional to the dose. Comparison of these results with those reported previously indicates that etoposide exhibits linear pharmacokinetics over a thirtyfold range in doses (0.1 to 3 gm/m2).