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Related Concept Videos

Longitudinal Studies01:26

Longitudinal Studies

374
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
374
Longitudinal Research02:20

Longitudinal Research

12.9K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Related Experiment Video

Updated: Dec 10, 2025

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
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A longitudinal study of the post-stroke immune response and cognitive functioning: the StrokeCog study protocol.

Lauren L Drag1, Michael Mlynash2, Huda Nassar3

  • 1Department of Neurology and Neurological Sciences, Stanford University Medical Center, 213 Quarry Rd, Palo Alto, CA, 94305, USA. ldrag@stanfordhealthcare.org.

BMC Neurology
|August 28, 2020
PubMed
Summary

This study investigates how immune responses after ischemic stroke impact long-term cognitive decline. Understanding these immune-cognition links may reveal new therapeutic targets for post-stroke cognitive impairment.

Keywords:
CognitionImmune systemNeuropsychologyProteomicsStrokeVascular dementia

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Area of Science:

  • Neuroscience
  • Immunology
  • Clinical Research

Background:

  • Stroke is a leading cause of long-term cognitive impairment.
  • The immunological mechanisms underlying post-stroke cognitive decline remain largely unknown.
  • The StrokeCog study aims to explore the link between immune responses and cognitive trajectories after ischemic stroke.

Purpose of the Study:

  • To examine the association between immunological responses and long-term cognitive trajectories in ischemic stroke survivors.
  • To investigate the role of immune system changes in cognitive decline following stroke.
  • To identify potential biomarkers for predicting cognitive outcomes after stroke.

Main Methods:

  • Prospective, observational, single-center cohort study.
  • Annual collection of comprehensive neuropsychological assessments, plasma/serum samples, and psychosocial data for up to 4 years.
  • Utilizes single-cell sequencing of monocytes and plasma proteomics to analyze immunological profiles.

Main Results:

  • The study is designed to enroll 210 participants, with an anticipated final sample size of 158 after attrition.
  • Statistical power calculations indicate the ability to detect significant cognitive changes.
  • Analysis will correlate detailed immunological measures with observed cognitive trajectories.

Conclusions:

  • The StrokeCog study will offer new insights into the relationship between immune system activity and cognitive changes occurring years after an ischemic stroke.
  • Findings may elucidate the immunological underpinnings of persistent cognitive deficits post-stroke.