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Items for consideration in a reporting guideline for mediation analyses: a Delphi study.

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Experts reached consensus on 34 reporting items for mediation analysis guidelines. This study identified key elements for transparent reporting of mediation analyses in research.

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Area of Science:

  • Quantitative research methods
  • Biostatistics
  • Epidemiology

Background:

  • Mediation analysis is crucial for understanding intervention effects in studies.
  • Standardized reporting guidelines are needed for mediation analyses.
  • Existing reporting practices for mediation analysis lack consensus.

Purpose of the Study:

  • To identify essential reporting items for mediation analysis guidelines.
  • To achieve expert consensus on critical reporting elements.
  • To inform the development of a robust reporting guideline for mediation analyses.

Main Methods:

  • International online Delphi study.
  • Involved 19 international experts in mediation analysis.
  • Utilized the Research ANd Development/University of California Los Angeles appropriateness method for consensus.

Main Results:

  • Consensus was achieved on 34 unique reporting items.
  • Three items were identified as 'optional' for reporting.
  • Expert panel provided qualitative feedback for item refinement.

Conclusions:

  • A rigorous consensus process identified 34 key reporting items for mediation analysis.
  • These findings will guide a consensus meeting to finalize reporting recommendations.
  • The developed guideline will enhance the transparency and quality of mediation analysis reporting.