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Published on: October 31, 2025
Initiation of respiratory support for extremely preterm infants at birth
Madeleine C Murphy1,2,3, Lisa K McCarthy1,2, Colm P F O'Donnell4,2
1Department of Neonatology, National Maternity Hospital, Dublin, Ireland.
Insights
Most extremely preterm infants received respiratory support shortly after birth, often without knowing their heart rate (HR). Many received positive pressure ventilation (PPV), but a quarter did not require it.
Area of Science:
- Neonatology
- Pediatric Critical Care
Background:
- Neonatal resuscitation guidelines emphasize assessing breathing and heart rate (HR) in newborns.
- Recommendations suggest continuous positive airway pressure (CPAP) over routine intubation for positive pressure ventilation (PPV) in preterm infants.
Purpose of the Study:
- To determine the prevalence and timing of respiratory support initiation for extremely preterm and extremely low birthweight (ELBW) infants.
- To analyze the adherence to current resuscitation guidelines in this vulnerable population.
Main Methods:
- Retrospective video review of 55 extremely preterm ELBW infants' resuscitation.
- Analysis of respiratory support methods and timing relative to HR assessment.
Main Results:
- Nearly all extremely preterm ELBW infants received respiratory support immediately upon arrival to the resuscitation cot.
- The majority received PPV, often without prior HR assessment.
- A significant quarter of infants were managed without any PPV.
Conclusions:
- Respiratory support is initiated very early for extremely preterm ELBW infants, sometimes preceding HR assessment.
- Current practices may not fully align with guidelines recommending HR assessment before intervention and considering CPAP for preterm infants.
Abstract:
Neonatal resuscitation algorithms recommend assessing breathing and heart rate (HR) of newborns and giving respiratory support when one or both are unsatisfactory. Recommendations also state that preterm infants may be supported with continuous positive airway pressure rather than routinely intubated for positive pressure ventilation (PPV). We wished to describe the prevalence and time of initiation of respiratory support of extremely preterm and extremely low birthweight (ELBW) infants at our hospital. We reviewed videos of 55 infants. Although most were breathing, practically all newly born extremely preterm ELBW infants were given respiratory support soon after arrival to the resuscitation cot. For the majority, this was done without knowing the HR. The majority received PPV; again, this was often done without knowing the HR. A quarter of infants were managed without any PPV.
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