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Related Experiment Videos

Diffuse dermal neutrophilia in urticaria.

R K Winkelmann1, G T Reizner

  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.

Human Pathology
|April 1, 1988
PubMed
Summary

Diffuse dermal neutrophilia, a pattern seen in urticaria, involves neutrophils in skin inflammation. This histologic finding is present in nearly 9% of urticaria cases, suggesting an intense response pattern.

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Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Urticaria is a common skin condition characterized by transient wheals.
  • The role of neutrophils in urticarial inflammation is not fully understood.
  • Diffuse dermal neutrophilia is a specific histologic pattern observed in some urticaria cases.

Purpose of the Study:

  • To review cases of diffuse dermal neutrophilia and urticaria.
  • To determine the prevalence of this pattern in urticaria.
  • To compare associated clinical features with urticaria without neutrophilia.

Main Methods:

  • Retrospective review of 23 cases with diffuse dermal neutrophilia and urticaria.
  • Histologic examination of skin biopsies.
  • Direct immunofluorescence studies in 19 cases.
  • Analysis of clinical data including angioedema, dermographism, atopy, drug reactions, and infections.

Main Results:

  • No evidence of vasculitis or other systemic disease was found.
  • Direct immunofluorescence was nonspecific in 14 of 19 cases.
  • Associated clinical features were similar to urticaria without neutrophilia.
  • Diffuse dermal neutrophilia was identified in 8.7% of urticaria cases.
  • Neutrophilic urticaria cases included, 15.8% of urticaria showed a significant neutrophil component.

Conclusions:

  • Diffuse dermal neutrophilia in urticaria is a distinct histologic pattern.
  • This pattern is not associated with vasculitis or other specific diseases.
  • Neutrophilia in urticaria may represent an intense stimulus response.

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