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Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study
Elzbieta Masiewicz1,2, George P Ashcroft3, David Boddie3
1Department of Physics and Biophysics, Faculty of Mathematics and Computer Science, University of Warmia and Mazury in Olsztyn, Słoneczna 54, 10-710, Olsztyn, Poland.
Scientific Reports
|August 28, 2020
Summary
Fast Field-Cycling Nuclear Magnetic Resonance (FFC-NMR) relaxometry can detect and characterize sarcoma by analyzing tissue microstructure and rigidity. This pilot study shows distinct FFC-NMR profiles for five sarcoma categories, guiding future patient analyses.
Area of Science:
- Biomedical Engineering
- Medical Physics
- Oncology
Background:
- Sarcomas are rare cancers requiring accurate diagnostic methods.
- Nuclear Magnetic Resonance (NMR) relaxometry offers insights into tissue properties.
- Fast Field-Cycling NMR (FFC-NMR) provides unique dynamic information.
Purpose of the Study:
- To explore the utility of FFC-NMR relaxometry for sarcoma characterization.
- To develop a quantitative method for analyzing NMR relaxation dispersion profiles in sarcoma tissues.
- To assess the potential of FFC-NMR for guiding in vivo patient analyses.
Main Methods:
- Ex vivo pilot study of 10 biopsy-proven sarcoma cases.
- Quantitative analysis of 1H NMR relaxation dispersion profiles using a model-free approach.
- Assessment of Quadrupole Relaxation Enhancement effects from 14N.
- Analysis of surrounding tumor tissues to evaluate proximity effects.
Main Results:
- Five distinct FFC-NMR relaxation dispersion profiles were identified, correlating with five sarcoma categories.
- Differences in profiles are attributed to variations in tissue microstructure and rigidity.
- Significant variations were observed in peritumoral tissues, related to water content and tumor-induced remodeling.
- FFC-NMR shows potential for sarcoma detection and characterization.
Conclusions:
- FFC-NMR relaxometry is a promising technique for differentiating sarcoma subtypes.
- The developed quantitative method provides insights into tissue dynamics and composition.
- FFC-NMR has the potential to aid in the clinical diagnosis and characterization of sarcomas.
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