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Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

Zhao-Shan Niu1, Wen-Hong Wang2, Xian-Ning Dong3

  • 1Laboratory of Micromorphology, School of Basic Medicine, Medical Department of Qingdao University, Qingdao 266071, Shandong Province, China. z.s.niu@qdu.edu.cn.

World Journal of Gastroenterology
|August 28, 2020
PubMed

Insights

Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) form regulatory networks in cancer. These interactions, particularly lncRNAs acting as competing endogenous RNAs (ceRNAs), are crucial in hepatocellular carcinoma (HCC) development and progression.

Area of Science:

  • Molecular Biology
  • Genomics
  • Oncology

Background:

  • Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate gene expression.
  • lncRNAs can function as competing endogenous RNAs (ceRNAs), modulating messenger RNA (mRNA) levels by interacting with miRNAs.
  • Dysregulation of these RNA interactions is implicated in tumorigenesis and cancer progression.

Purpose of the Study:

  • To review recent advances in the biological functions of lncRNAs as ceRNAs in hepatocellular carcinoma (HCC).
  • To elucidate the molecular mechanisms of lncRNA-ceRNA networks in HCC.
  • To provide insights into novel diagnostic and therapeutic strategies for HCC.

Main Methods:

  • Literature review of studies on lncRNA-mediated ceRNA networks in HCC.
  • Analysis of molecular mechanisms underlying ceRNA interactions in hepatocellular carcinoma.
  • Synthesis of current knowledge on the role of lncRNAs in HCC pathogenesis.

Main Results:

  • lncRNAs acting as ceRNAs play a significant role in the initiation and progression of HCC.
  • Perturbations in lncRNA-ceRNA interactions are linked to hepatocellular carcinoma development.
  • Numerous lncRNA-mediated ceRNA regulatory networks have been identified in HCC.

Conclusions:

  • lncRNA-ceRNA networks are integral to HCC pathogenesis.
  • Understanding these networks offers potential for novel HCC diagnostics and therapeutics.
  • Further research into lncRNA-ceRNA mechanisms can advance hepatocellular carcinoma treatment.
Keywords:
Competing endogenous RNAFunctionHepatocellular carcinomaLong noncoding RNAMechanismMicroRNA

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