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Blood Pressure is Associated with Rapid Kidney Function Decline in a Very Elderly Hypertensive Chinese Population

Kunhao Bai1,2, Rui Chen2, Fanghong Lu3

  • 1Department of Endoscopy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China.

Clinical Interventions in Aging
|August 28, 2020
PubMed

Insights

Systolic blood pressure (SBP) significantly increases the risk of rapid kidney function decline (RKFD) in elderly Chinese individuals with hypertension. Diastolic blood pressure (DBP) and pulse pressure (PP) did not show a significant association with RKFD risk.

Area of Science:

  • Nephrology
  • Geriatrics
  • Cardiology

Background:

  • Previous studies linked blood pressure (BP) to rapid kidney function decline (RKFD).
  • Limited research exists on this association in very elderly populations.
  • Hypertension is a common comorbidity in older adults, impacting kidney health.

Purpose of the Study:

  • To investigate the relationship between BP parameters and RKFD in Chinese individuals aged over 80 with hypertension.
  • To determine if systolic BP (SBP), diastolic BP (DBP), or pulse pressure (PP) are associated with accelerated kidney function loss in this specific demographic.

Main Methods:

  • A cohort of 284 hypertensive Chinese individuals over 80 years old was studied.
  • RKFD was defined as an estimated glomerular filtration rate (eGFR) decline exceeding 5 mL/min/1.73 m² per year.
  • Cox regression models were employed to analyze the association between SBP, DBP, PP, and RKFD risk.

Main Results:

  • Over a median follow-up of 3.3 years, 23.9% of participants developed RKFD.
  • Each 10 mmHg increase in SBP was associated with a 34% rise in RKFD risk (adjusted HR: 1.34, p=0.02).
  • Increases in DBP and PP showed no statistically significant association with RKFD risk in adjusted models.

Conclusions:

  • Systolic blood pressure is a significant predictor of rapid kidney function decline in very elderly hypertensive Chinese individuals.
  • Diastolic blood pressure and pulse pressure were not found to be significantly associated with RKFD in this population.
  • Findings highlight the importance of managing SBP in older hypertensive patients to preserve kidney function.
Abstract

Keywords:
Chinablood pressurerapid kidney function declinevery elderly

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