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Long Non-Coding Small Nucleolar RNA Host Genes (SNHGs) in Endocrine-Related Cancers

Yuan Qin1, Wei Sun1, Zhihong Wang1

  • 1Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, People's Republic of China.

Oncotargets and Therapy
|August 28, 2020
PubMed

Insights

Small nucleolar RNA host genes (SNHGs) are long non-coding RNAs (lncRNAs) implicated in cancer. This review explores SNHG functions in endocrine-related cancers like thyroid and breast cancer.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) regulate biological processes.
  • Some lncRNAs function as oncogenes or tumor suppressors in cancer.
  • Small nucleolar RNAs (snoRNAs) are involved in RNA processing.

Purpose of the Study:

  • To review the biological functions of SNHGs in endocrine-related cancers.
  • To explore the emerging mechanisms of SNHGs in cancer development and progression.

Main Methods:

  • Literature review of SNHGs in endocrine-related cancers.
  • Analysis of SNHG expression and function in thyroid, breast, pancreatic, ovarian, and prostate cancers.

Main Results:

  • SNHGs are abnormally expressed in multiple cancers.
  • SNHGs participate in cell proliferation, tumor progression, metastasis, and chemoresistance.
  • Specific SNHGs have distinct roles in endocrine-related cancers.

Conclusions:

  • SNHGs are critical regulators in endocrine-related cancers.
  • Understanding SNHG mechanisms can inform therapeutic strategies.
  • Further research into SNHGs holds promise for cancer treatment.
Keywords:
SNHGcancersendocrinelncRNA

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