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CYP2D6 Expression in Veterans Experiencing Opioid Overdose: A Postmortem Review

Julia Boyle1,2, Christopher J Stock1

  • 1Department of Pharmacy, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.

Pharmacogenomics and Personalized Medicine
|August 28, 2020
PubMed
Summary

This study found that 7% of opioid overdose deaths in veterans had the ultrarapid (UM) metabolizer phenotype for CYP2D6. However, the findings do not support the hypothesis that this phenotype is over-represented in opioid overdose deaths.

Keywords:
copy number variationcytochrome P450drug metabolismmortalitypharmacogenomicsphenotype

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