Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3.

Neuron·2026
Same author

Autophagy Is Required for Dopaminergic Axon Development and Confers Their Responsiveness to Guidance Cues.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Optogenetic-induced α-synuclein accumulation reveals early synaptic dysfunction in experimental models of Parkinson's disease.

NPJ Parkinson's disease·2025
Same author

Distinct Ultrastructural Properties and Plasticity of Synapses Formed by Adult-Born and Early-Born Interneurons in the Mouse Olfactory Bulb.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions.

Cell stem cell·2025
Same author

Calretinin-Expressing Neurons in the Basal Forebrain Specifically Contact Granule Cells in the Olfactory Bulb and Modulate Odor Learning.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Related Experiment Video

Updated: Dec 10, 2025

Author Spotlight: Comparative Imaging of Neural Activity in Awake and Freely Moving States
06:25

Author Spotlight: Comparative Imaging of Neural Activity in Awake and Freely Moving States

Published on: January 19, 2024

1.4K

Deciphering Brain Function by Miniaturized Fluorescence Microscopy in Freely Behaving Animals.

Sarah Malvaut1,2, Vlad-Stefan Constantinescu1,2, Harold Dehez3

  • 1CERVO Brain Research Center, Quebec City, QC, Canada.

Frontiers in Neuroscience
|August 28, 2020
PubMed
Summary

Miniature microscopes enable real-time brain activity monitoring in freely moving animals. This review explores the advantages, limitations, and future of mini-endoscopic imaging for neuroscience research.

Keywords:
Ca2+ imagingGCaMPGECIGRIN lensesanimal behaviormini-endoscopic imagingminiature endoscopes

More Related Videos

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
10:35

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

31.9K
Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents
14:02

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Published on: June 29, 2014

23.2K

Related Experiment Videos

Last Updated: Dec 10, 2025

Author Spotlight: Comparative Imaging of Neural Activity in Awake and Freely Moving States
06:25

Author Spotlight: Comparative Imaging of Neural Activity in Awake and Freely Moving States

Published on: January 19, 2024

1.4K
Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
10:35

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

31.9K
Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents
14:02

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Published on: June 29, 2014

23.2K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optical Imaging

Background:

  • Animal behavior is influenced by neural networks and environmental stimuli.
  • Optical tools are crucial for studying brain function in active animals.
  • Genetically encoded sensors and actuators are key for monitoring neural activity.

Purpose of the Study:

  • To review the advancements and applications of mini-endoscopic imaging in neuroscience.
  • To highlight the benefits of mini-microscopes for studying brain activity in freely behaving animals.
  • To discuss the current limitations and future directions of this technology.

Main Methods:

  • Review of recent literature on mini-endoscopic imaging techniques.
  • Discussion of genetically encoded tools for neuronal and glial activity monitoring.
  • Analysis of microscopy advancements, particularly miniature microscopes.

Main Results:

  • Miniature microscopes (mini-endoscopes) allow cellular and network-level brain activity studies in freely moving mice.
  • This technique facilitates longitudinal investigations during behavioral tasks.
  • Mini-endoscopic imaging offers significant advantages for neuroscience research.

Conclusions:

  • Mini-endoscopic imaging is a powerful tool for understanding brain function in naturalistic settings.
  • Further improvements in mini-endoscopic technology are expected to enhance research capabilities.
  • This technique is vital for bridging the gap between neural activity and behavior.