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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Dec 10, 2025

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics
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Stem Cells of the Aging Brain.

Alexandra M Nicaise1, Cory M Willis1, Stephen J Crocker2

  • 1Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom.

Frontiers in Aging Neuroscience
|August 28, 2020
PubMed
Summary

Aging impairs central nervous system stem cells, hindering brain repair and increasing neurodegeneration risk. Targeting aging neural stem cells (NSCs) offers new therapeutic avenues for brain diseases.

Keywords:
agingcell metabolismdisease modelingmitochondrianeural stem cellssenescencesenotherapeutics

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Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Aging Research

Background:

  • Adult central nervous system (CNS) harbors neural stem cells (NSCs) crucial for neurogenesis.
  • Physiological aging progressively diminishes NSC self-renewal and regenerative potential.
  • Age is a primary risk factor for neurodegenerative diseases, yet models often neglect aging effects.

Purpose of the Study:

  • To review intrinsic and extrinsic regulators of NSC aging.
  • To discuss the impact of aging factors on adult brain homeostasis.
  • To explore therapeutic strategies targeting aging NSCs for brain diseases.

Main Methods:

  • Review of established in vivo animal models.
  • Analysis of in vitro human disease model systems.
  • Examination of current and future senotherapeutics.

Main Results:

  • Aging affects NSC function through various intrinsic and extrinsic factors.
  • Dysfunctional aging NSCs contribute to neurodegenerative processes.
  • Senotherapeutics show promise in ameliorating age-related stem cell failure.

Conclusions:

  • Understanding NSC aging is critical for neurodegenerative disease research.
  • Integrating aging research with disease models is imperative for therapeutic discovery.
  • Targeting aging NSCs represents a promising strategy for treating brain disorders.