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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
COVID-19 Therapeutic Options Under Investigation
Malak Kaddoura1,2, Malak AlIbrahim1,2, Ghina Hijazi1,2
1Department of Experimental Pathology, Immunology & Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Effective treatments are crucial for managing COVID-19. This review examines potential antiviral and immunomodulatory therapies, including remdesivir and dexamethasone, to reduce mortality rates.
Area of Science:
- * Infectious Diseases and Virology
- * Clinical Pharmacology and Therapeutics
Background:
- * The global COVID-19 pandemic, caused by SARS-CoV-2, necessitates urgent development of effective treatments.
- * Vaccination and herd immunity are long-term strategies, but immediate therapeutic interventions are critical to reduce mortality.
- * Existing treatments like remdesivir and dexamethasone show promise in mitigating severe outcomes.
Purpose of the Study:
- * To review potential therapeutic agents for the treatment and management of COVID-19 patients.
- * To highlight ongoing preclinical and clinical studies of antiviral and immunomodulatory compounds.
Main Methods:
- * Comprehensive literature review of preclinical and clinical studies.
- * Analysis of antiviral and immunomodulatory compounds investigated for COVID-19 treatment.
- * Evaluation of existing therapeutic options, including remdesivir and dexamethasone.
Main Results:
- * Several antiviral and immunomodulatory agents are under investigation for COVID-19.
- * Remdesivir and dexamethasone have demonstrated efficacy in reducing COVID-19 associated mortality.
- * Ongoing research aims to identify safe and efficacious therapeutics.
Conclusions:
- * Effective treatments are urgently needed to combat the COVID-19 pandemic.
- * A range of therapeutic agents are being explored, with some showing significant promise.
- * Continued research is vital for developing optimal management strategies for COVID-19 patients.
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