Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Newtonian Fluid: Problem Solving01:18

Newtonian Fluid: Problem Solving

729
Newtonian fluids exhibit a constant viscosity, meaning their shear stress and shear strain rate are directly proportional. This property ensures a predictable and stable response to applied forces, maintaining a linear relationship between force and flow. Examples include water, air, and light oils, consistently demonstrating this proportional behavior regardless of external conditions.
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
729

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling.

Angiogenesis·2026
Same author

Nuclear SUN2 coordinates endothelial cell-matrix interactions to regulate blood vessel homeostasis and barrier function.

bioRxiv : the preprint server for biology·2026
Same author

The 129S1/SvlmJ mouse strain recapitulates severe hypertensive target organ damage under moderate angiotensin II-induced hypertension.

Scientific reports·2026
Same author

Changes in hemodynamics, cardiac energetics, and cell signaling pathways induced by veno-arterial extracorporeal membrane oxygenation with or without left ventricular active unloading.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Endothelial TRIM47 regulates blood-brain barrier integrity and cognition via the KEAP1/NRF2 signalling pathway in mice.

Communications biology·2026
Same author

Gender-Affirming Hormone Therapy and Vascular Health: Walking the Line Between Caution and Confidence.

European journal of preventive cardiology·2026

Related Experiment Video

Updated: Dec 10, 2025

Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress
07:17

Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress

Published on: August 2, 2019

6.5K

Fluid Shear Stress Sensing by the Endothelial Layer.

Etienne Roux1,2, Pauline Bougaran1, Pascale Dufourcq1

  • 1Inserm, UMR 1034, Biology of Cardiovascular Diseases, University of Bordeaux, Bordeaux, France.

Frontiers in Physiology
|August 28, 2020
PubMed
Summary

Wall shear stress (WSS) sensing by endothelial cells is crucial for vascular health, influencing blood flow and vessel remodeling. A dynamic set point theory and biotensegrity offer a framework for understanding WSS regulation and its role in disease.

Keywords:
angiogenesisendothelial cellregulation – physiologicalshear stresstensegrityvascular remodelingvasoreactivity

More Related Videos

Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers
08:50

Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers

Published on: October 21, 2018

9.3K
The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
09:20

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

Published on: October 31, 2016

8.4K

Related Experiment Videos

Last Updated: Dec 10, 2025

Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress
07:17

Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress

Published on: August 2, 2019

6.5K
Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers
08:50

Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers

Published on: October 21, 2018

9.3K
The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
09:20

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

Published on: October 31, 2016

8.4K

Area of Science:

  • Cardiovascular Physiology
  • Biophysics
  • Cell Biology

Background:

  • Blood flow generates wall shear stress (WSS) on the endothelial lining.
  • WSS sensing is a physiological process vital for vascular development and function.
  • Dysregulated WSS is linked to vascular pathologies.

Purpose of the Study:

  • Review endothelial cell responses to WSS.
  • Explore WSS sensor mechanisms and biotensegrity.
  • Analyze the WSS set point theory for physiological and pathological contexts.

Main Methods:

  • Literature review of WSS sensing mechanisms.
  • Analysis of endothelial cell behavior and vascular effects.
  • Conceptual analysis of WSS sensor hypotheses and theories.

Main Results:

  • Endothelial cells sense WSS, impacting vasoreactivity, morphogenesis, and remodeling.
  • Hypotheses on WSS sensors include biotensegrity and tensional prestress.
  • The dynamic WSS set point theory provides a framework for self-organized vascular regulation.

Conclusions:

  • Dynamic WSS set point theory and biotensegrity explain physiological WSS sensing.
  • These concepts offer insights into the shift from physiological WSS sensing to pathology.