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Blood Plasma Resistin and Atrial Fibrillation in Patients With Cardiovascular Disease

George Samanidis1,2, Anastasios Gkogkos1, Stefanos Bousounis1

  • 1Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Cardiology Research
|August 28, 2020
PubMed

Insights

Higher resistin levels are linked to permanent atrial fibrillation (AF) in cardiovascular disease patients. This finding suggests resistin may play a role in AF development and progression.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Atrial fibrillation (AF) significantly impacts patient quality of life and prognosis.
  • Resistin is a key mediator in inflammatory responses.
  • Understanding factors associated with AF is crucial for cardiovascular disease management.

Purpose of the Study:

  • To investigate the association between plasma resistin levels and permanent atrial fibrillation (PAF) in patients with cardiovascular disease.
  • To determine if resistin concentration differs between patients with and without PAF.

Main Methods:

  • A cohort of 146 cardiovascular disease patients was analyzed.
  • Plasma resistin concentrations were measured.
  • Patients were categorized into AF and NonAF groups for comparative analysis using regression models.

Main Results:

  • No significant demographic differences (age, gender, BMI) were found between groups.
  • Patients with PAF exhibited significantly higher median resistin levels (6.90 ng/mL) compared to the NonAF group (5.83 ng/mL).
  • Multivariate analysis confirmed resistin as an independent predictor associated with PAF.

Conclusions:

  • Plasma resistin levels are significantly higher in patients with permanent atrial fibrillation.
  • Resistin is associated with permanent atrial fibrillation in cardiovascular disease patients.
  • These findings highlight resistin's potential role in the pathophysiology of AF.
Abstract

Keywords:
Atrial fibrillationCardiovascular diseaseResistin

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