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Convalescent plasma therapy in a pregnant COVID-19 patient with a dramatic clinical and imaging response: A case
Ramezan Jafari1, Nematollah Jonaidi-Jafari2, Fatemeh Dehghanpoor3
1Radiology Department, Faculty of Medicine and Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran 18151777, Iran.
Insights
This case report highlights the effectiveness of convalescent plasma therapy (CPT) combined with Favipiravir in treating a pregnant patient with COVID-19. Further research is needed to determine optimal CPT protocols for coronavirus disease 2019.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Hematology
Background:
- Coronavirus disease 2019 (COVID-19) is a global pandemic with varied clinical presentations.
- Effective therapeutic options for COVID-19 remain limited, necessitating exploration of novel treatments.
Observation:
- A 26-year-old woman, 36 weeks pregnant with twins, was diagnosed with COVID-19.
- The patient received convalescent plasma therapy (CPT) alongside Favipiravir.
Findings:
- The patient demonstrated a dramatic positive response to the combined therapy.
- Convalescent plasma therapy, in conjunction with Favipiravir, showed significant efficacy in this case.
Implications:
- This case suggests CPT may be a valuable adjunct therapy for severe COVID-19, particularly in pregnant individuals.
- Further investigation is required to establish optimal CPT dosage, efficacy, safety, and its role in combination therapies for COVID-19.
Background:
Coronavirus disease 2019 (COVID-19) is a novel very contagious infection which was designated a pandemic in all countries of the world in April 2020. Its presentation varies from mild to severe infection, but the majority of infected patients have mild manifestations. Many therapeutic choices have been suggested to treat the infection, but none are fully effective.
Case Summary:
Herein we present a 26-year-old woman with a twin pregnancy at 36 wk and one day gestation with confirmed COVID-19 who responded dramatically to convalescent plasma therapy (CPT) and Favipiravir.
Conclusion:
Although this case report shows the efficacy of CPT in addition to usual medications used for COVID-19, there are many questions that need to be answered regarding dosage, para-clinical efficacy, side effects and combination therapy.
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