Related Experiment Video
Updated: Dec 10, 2025

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
Published on: December 4, 2020
Complicated SPG4 presenting with recurrent urinary tract infection.
Kinsi Oberoi1, Kabir S Grewal2,3, Leema Reddy Peddareddygari3,4
1Clarivate Analytics, Life Sciences Division, Philadelphia, PA, USA.
A novel SPAST gene mutation caused hereditary spastic paraplegia type 4 (SPG4), leading to neurogenic bladder and recurrent urinary tract infections in a patient. This case broadens understanding of SPG4 mutations and their impact.
Area of Science:
- Genetics
- Neurology
- Urology
Background:
- Recurrent urinary tract infections (UTIs) can be a symptom of underlying neurological conditions.
- Spastic paraparesis, a neurological sign, warrants investigation into potential genetic causes.
- Hereditary spastic paraplegia (HSP) is a group of inherited neurological disorders affecting leg movement.
More Related Videos
Related Concept Videos
Urinary Tract Infection II: Pathophysiology
Urinary Tract Infection I: Introduction
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Urinary Tract Infection IV: Nursing Management
Acute Pyelonephritis I: Introduction

