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Updated: Dec 10, 2025
Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
Published on: May 2, 2011
Development of vaccines for SARS-CoV-2
Wern Hann Ng1, Xiang Liu1, Suresh Mahalingam1
1Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University (Gold Coast Campus), Queensland, Australia.
The rapid spread of COVID-19 necessitates urgent vaccine development. This review examines various vaccine technologies, discussing their strengths and weaknesses for combating the SARS-CoV-2 pandemic.
Area of Science:
- Immunology
- Virology
- Public Health
Background:
- The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019.
- Limited pre-existing natural immunity in human populations presents a significant challenge.
- The global spread necessitates rapid development of effective vaccines and therapeutics.
Purpose of the Study:
- To provide a concise overview of current vaccine development technologies for COVID-19.
- To analyze the advantages and disadvantages of diverse vaccine platforms.
- To inform ongoing research and public health strategies.
Main Methods:
- Review of scientific literature and ongoing clinical trials.
- Comparative analysis of different vaccine technologies (e.g., mRNA, viral vector, inactivated virus).
- Assessment of technological readiness and potential efficacy.
Main Results:
- Multiple vaccine technologies are being pursued globally.
- Each platform presents unique strengths, such as speed of development or established safety profiles.
- Challenges include manufacturing scalability, distribution, and long-term efficacy.
Conclusions:
- A diverse range of vaccine technologies are in development for COVID-19.
- Understanding the trade-offs of each approach is crucial for successful pandemic response.
- Continued investment and collaboration are vital for global vaccine accessibility.
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