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Related Experiment Video

Updated: Dec 10, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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Positive Chest CT Features in Patients With COVID-19 Pneumonia and Negative Real-Time Polymerase Chain Reaction Test.

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  • 1Radiology, West Hertfordshire Hospitals NHS Trust, Watford and St. Albans City Hospitals, London, GBR.

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|August 28, 2020
PubMed
Summary

Computed tomography (CT) scans can reveal characteristic lung changes of coronavirus disease (COVID-19) pneumonia, even when initial and repeat real-time polymerase chain reaction (RT-PCR) tests are negative. This highlights CT

Keywords:
2019-ncovchest ctcovid-19novel coronavirusrt-pcrsars-cov-2

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Area of Science:

  • Radiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Clinically suspected coronavirus disease (COVID-19) pneumonia may present with typical computed tomography (CT) chest scan findings.
  • Real-time polymerase chain reaction (RT-PCR) testing can yield false-negative results in some COVID-19 cases.

Purpose of the Study:

  • To describe the CT imaging characteristics of COVID-19 pneumonia in patients with negative RT-PCR results.
  • To evaluate the utility of chest CT in diagnosing COVID-19 when RT-PCR testing is inconclusive.

Main Methods:

  • Retrospective review of chest CT scans from 19 patients diagnosed with COVID-19.
  • Selection of five patients with typical CT findings despite two negative RT-PCR tests.
  • Analysis of CT scans for opacification density, disease distribution, and severity scoring by two radiologists.

Main Results:

  • Five out of 19 patients (26%) showed typical COVID-19 CT findings despite negative RT-PCR results.
  • CT findings included ground-glass opacities (GGO) and consolidation, predominantly bilateral, posterior, and peripheral.
  • CT severity scores ranged from 5 to 14, indicating mild, moderate, and severe disease.

Conclusions:

  • Chest CT is a valuable tool for diagnosing COVID-19 pneumonia, especially when RT-PCR results are negative.
  • Radiological findings on CT can confirm COVID-19 in the presence of clinical suspicion, even with repeated negative molecular tests.
  • Lung parenchymal changes indicative of COVID-19 are clearly visible on CT scans irrespective of RT-PCR outcomes.