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Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
Published on: February 21, 2016
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Unspecified live kidney donation by urological patients
Sebastiaan Ceuppens1, Hendrikus J A N Kimenai1, Karel W J Klop1
1Division of Transplant Surgery, Department of Surgery, Erasmus MC University Medical Center, Rotterdam 3015GD, Netherlands.
World Journal of Transplantation
|August 28, 2020
Summary
Patients with benign kidney disorders needing nephrectomy can donate a kidney. This study shows selected donors experienced pain relief and maintained good kidney function post-donation.
Area of Science:
- Nephrology
- Transplantation Surgery
- Urology
Background:
- Nephrectomy for benign kidney disorders presents options: autotransplantation, discarding the kidney, or living donation.
- Living kidney donation is an option, but suitability for patients with pre-existing kidney conditions requiring nephrectomy is less understood.
Purpose of the Study:
- To evaluate the feasibility and outcomes of using patients with benign kidney disorders requiring nephrectomy as unspecified live kidney donors.
- To assess the safety and efficacy of kidney donation in this unique donor population.
Main Methods:
- Retrospective analysis of clinical data from 1994-2019 involving unspecified kidney donors and recipients (n=160).
- Focused on nine donors with pre-existing kidney disorders necessitating nephrectomy who opted for anonymous donation.
- Monitored the clinical course of these nine donors and their transplant recipients.
Main Results:
- Seven of nine donors had loin pain as their primary symptom, with post-nephrectomy pain relief reported by most.
- Donating patients maintained stable kidney function, with average creatinine levels of 88 µmol/L at 1 year and 86.6 µmol/L at a median of 6.9 years.
- Transplant recipients experienced good outcomes, with all recipients now off dialysis despite one major complication and one case of delayed graft function.
Conclusions:
- Selected patients undergoing nephrectomy for specific benign kidney disorders are suitable candidates for live kidney donation.
- Kidney donation in this cohort can lead to positive outcomes for both the donor and the recipient, including symptom improvement for the donor.
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