Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

6.6K
Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
6.6K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.6K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.6K
Bone Remodeling01:40

Bone Remodeling

39.9K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
39.9K
Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

2.8K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.8K
Endoplasmic Reticulum01:39

Endoplasmic Reticulum

104.9K
The Endoplasmic Reticulum (ER) in eukaryotic cells is a substantial network of interconnected membranes with diverse functions, from calcium storage to biomolecule synthesis. A primary component of the endomembrane system, the ER manufactures phospholipids critical for membrane function throughout the cell. Additionally, the two distinct regions of the ER specialize in the manufacture of specific lipids and proteins.
104.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4.

Cell research·2025
Same author

Osteoimmunology in bone malignancies: a symphony with evil.

Journal of the National Cancer Center·2024
Same author

Development of a RIPK1 degrader to enhance antitumor immunity.

Nature communications·2024
Same author

Association between systemic inflammation markers and cardiovascular mortality in adults with metabolic dysfunction-associated steatotic liver disease.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2024
Same author

GPR37 and its neuroprotective mechanisms: bridging osteocalcin signaling and brain function.

Frontiers in cell and developmental biology·2024
Same author

The application value of metagenomic next-generation sequencing technology in the detection of pathogens in patients with pneumonia after initial treatment failure.

Asian journal of surgery·2024

Related Experiment Video

Updated: Dec 10, 2025

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

17.2K

Endoplasmic Reticulum Stress in Bone Metastases.

Longyong Xu1,2,3, Weijie Zhang1,2,3, Xiang H-F Zhang1,2,3

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States.

Frontiers in Oncology
|August 28, 2020
PubMed
Summary

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are activated during cancer metastasis to bone. Understanding their roles may reveal new therapeutic targets for bone metastases.

Keywords:
ER stressbone metastasesimmunotherapymetastatic nicheseed and soilunfolded protein response

More Related Videos

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

24.7K
Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

42.8K

Related Experiment Videos

Last Updated: Dec 10, 2025

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

17.2K
Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

24.7K
Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

42.8K

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Metastasis, the spread of cancer cells, is a major cause of cancer morbidity and mortality.
  • Bone metastases are often incurable and significantly impact patient quality of life.
  • Emerging evidence links endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) to cancer cell dissemination.

Purpose of the Study:

  • To review recent findings on the role of ER stress and UPR in bone metastasis.
  • To explore the tumorigenic, immunoregulatory, and metastatic effects of ER stress and UPR in the context of bone.
  • To identify potential therapeutic strategies targeting ER stress and UPR for bone metastases.

Main Methods:

  • Literature review of recent scientific publications.
  • Synthesis of current knowledge on ER stress, UPR, and bone metastasis.
  • Analysis of potential therapeutic implications.

Main Results:

  • ER stress and UPR are activated during the metastatic process to bone.
  • These pathways influence tumor growth, immune evasion, and colonization in bone.
  • Current research highlights the complex interplay between ER stress, UPR, and bone microenvironment.

Conclusions:

  • Targeting ER stress and UPR pathways presents a promising avenue for novel therapies against bone metastases.
  • Further research is needed to fully elucidate the mechanisms and translate findings into clinical practice.
  • Understanding these molecular pathways is critical for developing effective treatments for patients with bone metastases.