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The Role of GSK3β in T Lymphocytes in the Tumor Microenvironment

Anastasios Dimou1, Konstantinos N Syrigos2

  • 1Division of Medical Oncology, Mayo Clinic, Rochester, MN, United States.

Frontiers in Oncology
|August 28, 2020
PubMed

Insights

Glycogen synthase kinase 3 beta (GSK3β) plays a role in cancer immunity. Inhibiting GSK3β may enhance immunotherapy by modulating the tumor microenvironment.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Cancer immunotherapies leverage T cell responses against tumor antigens.
  • Glycogen synthase kinase 3 beta (GSK3β) is a key kinase regulating diverse cellular functions, including immune cell activity.

Purpose of the Study:

  • To review the potential role of GSK3β in the tumor immune microenvironment.
  • To guide future research on GSK3β inhibition as an immunotherapy strategy.

Main Methods:

  • Literature review of GSK3β's function in cellular processes.
  • Analysis of GSK3β's impact on immune cells within the tumor microenvironment.

Main Results:

  • GSK3β has multifaceted roles in cell function, impacting immune cells.
  • GSK3β inhibitors are readily available for research and clinical applications.

Conclusions:

  • GSK3β inhibition presents a potential therapeutic avenue to augment cancer immunotherapy.
  • Further research is warranted to explore GSK3β's role in the tumor immune microenvironment.
Keywords:
GSK3βIL-10NFAT2PD-L1Tregs

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