Phyto-Immunotherapy, a Complementary Therapeutic Option to Decrease Metastasis and Attack Breast Cancer Stem Cells

Area of Science:

• Oncology
• Immunology
• Pharmacology

Background:

• Breast cancer stem cells (BCSCs) drive chemoresistance and metastasis.
• Targeting BCSCs and enhancing immune response are critical therapeutic goals.

Purpose of the Study:

• To review the role of natural products in overcoming chemoresistance and metastasis in breast cancer.
• To explore the potential of natural products to synergize with chemotherapy and modulate the immune system.

Main Methods:

• Literature review of studies on natural products, BCSCs, chemotherapy, and immune response.
• Keywords used: "immune response," "polyphenols," "natural products," "BCSC," "therapy," "metabolism," "immunogenic cell death."
• Focus on recent scientific publications in PubMed and Google Scholar.

Main Results:

• Natural products, like P2Et, show potential in increasing tumor sensitivity to chemotherapy.
• These compounds may restore the tumor microenvironment and induce a specific immune response.
• Synergistic effects could lead to the destruction of BCSCs and reduced metastasis.

Conclusions:

• Natural products offer a promising strategy to combat chemoresistant breast cancer.
• Their ability to enhance chemotherapy and activate anti-tumor immunity warrants further investigation.
• Targeting BCSCs with natural products could significantly improve patient outcomes.