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Updated: Dec 10, 2025

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
06:19

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

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Malassezia spp. Yeasts of Emerging Concern in Fungemia

Wafa Rhimi1, Bart Theelen2, Teun Boekhout2,3,4

  • 1Dipartimento di Medicina Veterinaria, Università degli Studi "Aldo Moro", Bari, Italy.

Frontiers in Cellular and Infection Microbiology
|August 28, 2020
PubMed

Insights

Malassezia yeasts, often found on skin, can cause infections and fungemia, especially in immunocompromised individuals. This review covers recent findings on Malassezia infections, focusing on epidemiology, diagnostics, and treatments.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Malassezia yeasts are lipid-dependent fungi residing on skin and mucosa.
  • They are implicated in various skin conditions and can cause fungemia in immunocompromised patients.
  • Despite increased research, Malassezia fungemia epidemiology is underestimated due to isolation challenges.

Purpose of the Study:

  • To review and discuss recent literature on Malassezia spp. infections and fungemia.
  • To summarize current knowledge on occurrence, pathogenicity, and diagnostics.
  • To cover in vitro susceptibility testing and therapeutic strategies.

Main Methods:

  • Literature review of recent scientific publications.
  • Synthesis of data on Malassezia epidemiology and clinical significance.
  • Analysis of diagnostic methods and treatment options.

Main Results:

  • Malassezia fungemia is an underrecognized clinical entity.
  • Lipid-dependence poses challenges for yeast isolation and diagnosis.
  • Recent advances have improved understanding of pathogenicity and susceptibility.

Conclusions:

  • Further research is needed to fully elucidate Malassezia fungemia epidemiology.
  • Improved diagnostic and therapeutic strategies are crucial for patient management.
  • Understanding Malassezia's role in infections is vital for clinical practice.
Keywords:
Malassezia spp.antifungal profilediagnosisepidemiologyfungemiapathogenesistherapy

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