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Insulin: Trigger and Target of Renal Functions
Ana F Pina1,2,3, Diego O Borges1,4, Maria João Meneses1,2
1Centro de Estudos de Doenças Crónicas, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
Frontiers in Cell and Developmental Biology
|August 28, 2020
Summary
The kidney
Area of Science:
- Nephrology
- Metabolic Science
- Endocrinology
Background:
- Kidney's role in metabolism is underestimated.
- Insulin metabolism involves kidney degradation and action.
- Fasting and feeding states alter kidney insulin dynamics.
Purpose of the Study:
- Review renal insulin actions and clearance.
- Examine kidney dysmetabolism links to insulin resistance and hyperinsulinemia.
Main Methods:
- Literature review of renal physiology and metabolism.
- Analysis of insulin's role in nephron function.
- Exploration of metabolic disease associations.
Main Results:
- Kidney balances insulin degradation and utilization for homeostasis.
- Insulin impacts nephron function, influencing electrolyte and acid-base balance.
- Kidney dysmetabolism is linked to insulin resistance.
Conclusions:
- Understanding renal insulin dynamics is key to metabolic health.
- Kidney dysfunction contributes to insulin resistance and hyperinsulinemia.
- Further research into kidney's metabolic roles is warranted.
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