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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Related Experiment Video

Updated: Dec 10, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

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CD226: An Emerging Role in Immunologic Diseases.

Zhiyi Huang1, Guangyin Qi1, Joseph S Miller2

  • 1Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.

Frontiers in Cell and Developmental Biology
|August 28, 2020
PubMed
Summary

CD226, a protein on immune cells, is increasingly linked to autoimmune diseases, infections, and tumors. This review explores its structure, function, and role in disease for future research.

Keywords:
CD226adhesion factorautoimmune diseaseimmunetumor

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

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Last Updated: Dec 10, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

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Murine Model of CD40-activation of B cells
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Area of Science:

  • Immunology
  • Molecular Biology
  • Pathophysiology

Background:

  • CD226 is an immunoglobulin superfamily member expressed on natural killer and T cells.
  • Emerging research highlights CD226's significant role in various disease states.

Purpose of the Study:

  • To review the structure, mechanism of action, and pathophysiological roles of CD226.
  • To provide a foundation for further investigation into CD226 in disease.

Main Methods:

  • Literature review and synthesis of existing research on CD226.

Main Results:

  • CD226 is implicated in the pathogenesis of autoimmune disorders.
  • CD226 plays a role in the immune response to infectious diseases.
  • CD226 is associated with the development and progression of tumors.

Conclusions:

  • Understanding CD226's function is crucial for developing targeted therapies.
  • Further research into CD226 is warranted for its therapeutic potential in diverse diseases.