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USP7 Is a Master Regulator of Genome Stability

Gabrielle J Valles1, Irina Bezsonova1, Roger Woodgate2

  • 1Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, United States.

Frontiers in Cell and Developmental Biology
|August 28, 2020
PubMed
Summary

Genetic alterations drive cancer by disrupting genome stability. The enzyme ubiquitin specific protease 7 (USP7) is crucial for this stability and its deregulation promotes cancer progression, suggesting USP7 as a therapeutic target.

Keywords:
DNA repaircancergenomic integritymutagenesisreplicationtumor suppressor protein p53ubiquitin

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