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[Reference values of beta 2 microglobulin concentrations in the serum of children]
1Universitäts-Kinderklinik Bonn.
Klinische Padiatrie
|January 1, 1988
Insights
Beta 2-microglobulin levels in children decrease significantly after birth, stabilizing by the first year. These findings are crucial for understanding pediatric reference ranges for beta 2-microglobulin.
Area of Science:
- Biochemistry
- Pediatric Medicine
- Clinical Chemistry
Context:
- Establishing normative data for serum beta 2-microglobulin is essential for pediatric health assessment.
- Beta 2-microglobulin is a protein found on the surface of most nucleated cells, often used as a marker for cell turnover and immune function.
Purpose:
- To determine the age-dependent changes in serum beta 2-microglobulin concentrations in healthy children.
- To establish reference ranges for beta 2-microglobulin in pediatric populations.
Summary:
- Serum beta 2-microglobulin was measured in 271 healthy children (156 males, 115 females) using competitive enzyme immunoassay.
- Results indicate a significant age-dependent decrease in beta 2-microglobulin levels.
- Newborn values (2.84-3.38 mg/l) decline by the first year, stabilizing around 1.48-1.56 mg/l.
Impact:
- Provides crucial reference ranges for pediatric serum beta 2-microglobulin, aiding in the diagnosis and monitoring of various pediatric conditions.
- Highlights the importance of age-specific interpretation of beta 2-microglobulin levels in children.
- Contributes to the understanding of protein dynamics and immune system development in early life.
Abstract:
Concentrations of beta 2-microglobulin were determined using a competitive enzyme immunoassay in blood serum of 271 "healthy" children (male = 156, female = 115). The concentration of beta 2-microglobulin in children is age dependent. The values of the newborn 2.84-3.38 mg/l (95% confidence interval) decrease till the first year and stabilize later on between 1.48-1.56 mg/l (95% confidence interval).