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Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

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Treatment Options for COVID-19: A Review.

Mukarram Jamat Ali¹, Muhammad Hanif², Muhammad Adnan Haider³

¹Department of Medicine, King Edward Medical University, Lahore, Pakistan.

Frontiers in Medicine

|August 28, 2020

Summary

This summary is machine-generated.

The COVID-19 pandemic requires urgent treatment solutions. Reviewing existing antiviral and antimicrobial agents for repurposing may offer effective options against SARS-CoV-2, necessitating further clinical trials.

Keywords:

COVID-19 SARS-CoV-2 chloroquine/hydroxychloroquine immunoglobulin ivermectin remdesivir tocilizumab

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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Area of Science:

Infectious Diseases
Virology
Public Health

Background:

The COVID-19 pandemic, caused by SARS-CoV-2, presents significant global health challenges due to limited understanding of viral dynamics and effective treatments.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in substantial morbidity and mortality worldwide.
The full economic impact of the pandemic is yet to be determined.

Purpose of the Study:

To review existing evidence on COVID-19 treatment options.
To explore future pandemic management strategies and identify revolutionary treatment approaches.
To emphasize the importance of repurposing existing antiviral and antimicrobial agents for rapid response and the need for global clinical trials.

Main Methods:

Comprehensive literature search of case reports, retrospective analyses, and in vitro studies.
Databases searched include PubMed, EMBASE, and Google Scholar.
Focus on treatment options for SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify promising therapeutic strategies.

Main Results:

SARS-CoV-2, while less lethal than SARS-CoV and MERS-CoV, poses a greater threat due to its high infectivity.
Currently, no specific vaccine or universally effective drug regimen exists for COVID-19.
Drug repurposing of existing antivirals and potential combination therapies show promise.

Conclusions:

The COVID-19 pandemic is a historical global health crisis.
Repurposing established antiviral medications could provide immediate therapeutic benefits.
Further multicenter global randomized controlled trials are crucial to validate the efficacy of single agents or drug cocktails for COVID-19 treatment.