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Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
Published on: October 11, 2017
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Salicylate increased ascorbic acid levels and neuronal activity in the rat auditory cortex
Qingchuan Duan1,2, Furong Ma1, Jie Zhang2
1Department of Otolaryngology Head and Neck Surgery Peking University Third Hospital Beijing China.
Pediatric Investigation
|August 28, 2020
Summary
Ascorbic acid (AA) levels increase in the auditory cortex during tinnitus. This elevation in AA may be linked to heightened neural activity, suggesting a mechanism for tinnitus.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Tinnitus Research
Background:
- Clinical observations suggest a central origin for tinnitus.
- Ascorbic acid (AA) may have therapeutic effects on tinnitus, but mechanisms are unclear.
Purpose of the Study:
- To investigate changes in ascorbic acid (AA) levels and neural activity in the auditory cortex (AC) during salicylate-induced tinnitus.
Main Methods:
- Rats were administered saline, sodium salicylate (SS), or SS with AC lidocaine via microdialysis.
- In vivo microdialysis measured AA concentrations in the AC.
- Single-unit recordings assessed neural activity in the AC.
Main Results:
- Sodium salicylate (SS) significantly increased AA concentration and neuronal firing rate in the auditory cortex (AC).
- Lidocaine treatment partially reversed these SS-induced changes.
- The proportion of short interval discharges also increased with SS and was reversed by lidocaine.
Conclusions:
- Elevated AA levels in the auditory cortex (AC) correlate with increased neuronal activity.
- This AA elevation may represent a key mechanism in salicylate-induced tinnitus.
