Related Experiment Video
Updated: Dec 10, 2025
07:25
Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
4.5K
Sacroiliitis in Systemic Lupus Erythematosus Revisited
Neslihan Yilmaz1, Ayten Yazici2, Banu Özulu TÜrkmen3
1Department of Internal Medicine, Division of Rheumatology, Demiroğlu Bilim University Medial Faculty, Istanbul, Turkey.
Archives of Rheumatology
|August 28, 2020
Summary
Inflammatory back pain (IBP) is more common in systemic lupus erythematosus (SLE) patients. However, IBP in SLE is not linked to human leukocyte antigen B27 (HLA-B27) presence.
Area of Science:
- Rheumatology
- Immunology
- Systemic Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Inflammatory back pain (IBP) and sacroiliitis are potential manifestations.
- The association of IBP with human leukocyte antigen B27 (HLA-B27) in SLE is not well-defined.
Purpose of the Study:
- To determine the prevalence of IBP and sacroiliitis in SLE patients.
- To investigate the association between IBP and HLA-B27 status in this population.
Main Methods:
- A cohort of 281 SLE patients and 100 healthy controls (HCs) were assessed.
- The Assessment of SpondyloArthritis international Society-IBP questionnaire was utilized.
- Clinical, laboratory, and radiographic evaluations (X-ray, MRI) were performed to detect sacroiliitis.
Main Results:
- IBP was identified in 16.3% of SLE patients, compared to 0% in HCs (p<0.001).
- Sacroiliitis was detected in 7.8% of SLE patients via imaging.
- Only one SLE patient with sacroiliitis tested positive for HLA-B27.
Conclusions:
- IBP is significantly more prevalent in SLE patients than in the general population.
- There is no apparent association between IBP and HLA-B27 in SLE patients.
Related Concept Videos
01:19Abdominal Regions and Quadrants
15.0K
To promote clear communication, for instance, about the location of a patient's abdominal pain or a suspicious mass, anatomists and clinicians typically use imaginary lines to categorize the abdominopelvic cavity into either four quadrants or nine regions to identify organs in the cavity.
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four...
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four...
15.0K
01:24Nephrotic Syndrome I : Introduction
346
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
346
01:17Chronic Bowel Disorders: Introduction
668
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
668