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Updated: Dec 10, 2025

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
Published on: April 1, 2019
Successful reconstruction of an intrathoracic tracheal defect using a muscle flap and conchal cartilage graft
Kosuke Maitani1, Makoto Yamasaki2, Naoya Otani1
1Department of Plastic Surgery, Osaka University Graduate School of Medicine, 2-2-C11 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan.
Background:
Malignant invasion of the respiratory tract is a common complication in advanced cases of esophageal carcinoma. Resection and reconstruction can be extremely challenging, particularly when the invasion is intrathoracic. A circumferential tracheal resection with direct tracheal closure or mediastinal tracheostomy is often performed, but the outcome is not always favorable, with high morbidity rates, loss of vocal function, and reduced quality of life.
Methods:
We present our experience in performing an intrathoracic tracheal reconstruction in which a conchal cartilage graft was used in combination with a pectoralis major muscle transposition.
Results:
This was successfully done following the noncircumferential resection of the intrathoracic trachea due to mural invasion by a metastatic lymph node of esophageal carcinoma.
Conclusions:
We believe this report will contribute to the growing body of clinical expertise on procedures for intrathoracic tracheal reconstruction.
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