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Updated: Dec 10, 2025
Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain
Published on: December 12, 2017
Template-Directed Quantitative One-Pot Synthesis of Homochiral Helical Receptors Enabling Enantioselective Binding
Kyung Mog Kim1, Geunmoo Song1, Seungwon Lee1
1Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea.
Abstract:
Template-directed synthesis and dynamic covalent chemistry were implemented to achieve quantitative one-pot syntheses of homochiral helical cavities inside aromatic foldamers. One-handed helical receptors P-1, M-1, P-2 and M-2 were assembled from their precursors in the presence of appropriate templates (d- and l-tartaric acid, and d- and l-sorbitol, respectively) via three sequential steps in one pot: imine-linked chain elongation, template-induced folding and [4+2] cycloaddition between helical turns. These helical receptors were proven to enantioselectively bind chiral guests used as the templates, and the differences between the association constants of enantiomeric guests were up to more than two orders of magnitude. The structures and binding modes of the receptors were fully characterized by single-crystal X-ray crystallography and 1 H NMR spectroscopy.
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