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Cardio-Cerebrovascular Disease is Associated With Severity and Mortality of COVID-19: A Systematic Review and

Jia-Ning Yu1, Bing-Bing Wu1, Jie Yang1

  • 1School of Medicine, 66479Nantong University, Jiangsu, People's Republic of China.

Biological Research for Nursing
|August 28, 2020
PubMed

Insights

COVID-19 patients with cardio-cerebrovascular disease face a significantly higher risk of severe illness and death. This meta-analysis confirms a strong association, highlighting the need for focused nursing care for these vulnerable individuals.

Area of Science:

  • Cardiology
  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • COVID-19 pandemic has highlighted the impact of comorbidities on patient outcomes.
  • Diabetes and hypertension are known to worsen COVID-19 severity.
  • The effect of cardio-cerebrovascular disease on COVID-19 prognosis remained unclear.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between cardio-cerebrovascular disease and COVID-19 severity and mortality.
  • To compare the impact of cardiovascular versus cerebrovascular disease on COVID-19 outcomes.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, and CNKI databases up to July 25.
  • Random-effect model meta-analysis to calculate overall odds ratios (OR) with 95% confidence intervals (CIs).
  • Publication bias assessed using funnel plots and Begg's/Egger's tests.

Main Results:

  • Thirty-one studies including 23,632 patients were analyzed.
  • Cardio-cerebrovascular disease was associated with increased COVID-19 severity (OR = 3.004) and mortality (OR = 5.587).
  • Cerebrovascular disease showed a stronger association with increased severity (OR = 3.400) and mortality (OR = 23.477) compared to cardiovascular disease.

Conclusions:

  • Cardio-cerebrovascular disease is a significant risk factor for severe illness and death in COVID-19 patients.
  • Cerebrovascular disease poses a greater risk than cardiovascular disease for adverse COVID-19 outcomes.
  • Healthcare providers, particularly nurses, should prioritize monitoring and care for COVID-19 patients with cardio-cerebrovascular conditions.

Keywords:
COVID-19cardio-cerebrovascular diseasemeta-analysisseverity; mortality

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