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Updated: Dec 10, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and
Yanan Li1, Linawati Sutrisno, Yanhua Hou
1School of Life Science, Chongqing University, Chongqing 400044, China. menghuanli@cqu.edu.cn luozhong918@cqu.edu.cn.
Abstract:
A tumor redox-activatable micellar nanoplatform based on the naturally occurring biomacromolecule hyaluronic acid (HA) was developed for complementary photodynamic/chemotherapy against CD44-positive tumors. Here HA was first conjugated with l-carnitine (Lc)-modified zinc phthalocyanine (ZnPc) via disulfide linkage and then co-assembled with tirapazamine (TPZ) to afford the physiologically stable micellar nanostructure. The mitochondria-targeted photodynamic activity of ZnPc-Lc could efficiently activate the mitochondrial apoptosis cascade and deplete the oxygen in the tumor intracellular environment to amplify the hypoxia-dependent cytotoxic effect of TPZ.

