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Merkel Cell Polyomavirus Infection and Detection
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[MERKEL CELL CARCINOMA: A RETROSPECTIVE STUDY].

Ori Samuel Duek1, Yeela Ben Naftali1, Yehuda Ullmann1

  • 1Plastic and Reconstructive Surgery Department, Rambam Health Care Campus, Haifa, Israel.

Harefuah
|August 28, 2020
PubMed
Summary

This study suggests a potential link between diabetes and Merkel Cell Carcinoma (MCC), an aggressive skin cancer. Findings may help explain rising MCC incidence and inform treatment for this dangerous disease.

Area of Science:

  • Oncology
  • Dermatology
  • Epidemiology

Background:

  • Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine skin cancer with increasing incidence.
  • The prevalence of MCC has tripled in recent decades, necessitating further research into contributing factors.

Purpose of the Study:

  • To characterize a cohort of MCC patients treated at a northern Israeli referral center.
  • To compare patient demographics, clinical course, and outcomes with existing literature.

Main Methods:

  • Retrospective review of 18 MCC patients treated between 2011-2016.
  • Analysis of patient demographics, medical history, histology, systemic involvement, adjuvant therapy, recurrence, and survival rates.

Main Results:

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  • The cohort comprised predominantly elderly, male, Caucasian patients; some were immunocompromised.
  • A significant association was observed between diabetes and MCC, with 50% of patients having diabetes, a rate five times higher than the general population.
  • Metastases were present in 20% at diagnosis, lymph node involvement occurred in one-third during surgery, leading to 50% recurrence and 40% five-year mortality.

    • Conclusions:

    • The study provides initial evidence suggesting a potential association between diabetes and Merkel Cell Carcinoma.
    • This association may contribute to the observed rise in MCC incidence.
    • Treatment guidelines for metastatic MCC were established, incorporating immunotherapy to potentially improve patient prognosis.