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Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Coronary Artery Disease II: Pathophysiology01:26

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Endocarditis I: Introduction01:25

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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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The pathophysiology of pneumonia involves the following steps:
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Related Experiment Video

Updated: Dec 10, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
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Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

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Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses.

Eleni Gavriilaki1, Panagiota Anyfanti1, Maria Gavriilaki2

  • 13rd Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Current Hypertension Reports
|August 28, 2020
PubMed
Summary

Severe COVID-19 infection shares pathways with endothelial dysfunction, a condition seen in prior coronavirus infections. Understanding this link is key to managing the pandemic.

Keywords:
COVID-19ComplementEndothelial dysfunctionSARS-COV-2ThrombosisThrombotic microangiopathy

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Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Pathophysiology

Background:

  • Endothelial dysfunction is implicated in various viral infections, including prior coronavirus outbreaks.
  • Severe COVID-19 symptoms mirror the clinical presentation of endothelial dysfunction.
  • Mutual pathophysiological pathways are suggested between COVID-19 and endothelial dysfunction.

Purpose of the Study:

  • To review literature on endothelial dysfunction in previous coronavirus infections.
  • To present data on the role of endothelial dysfunction in COVID-19 pathophysiology and clinical phenotype.

Main Methods:

  • Literature review of current scientific evidence.
  • Analysis of preclinical and clinical studies on SARS-CoV-2.
  • Synthesis of findings related to endothelial cell function.

Main Results:

  • Evidence links severe COVID-19 to endothelial dysfunction.
  • Endothelial dysfunction appears to be a common factor in severe COVID-19 manifestations.
  • Pathophysiological similarities exist between COVID-19 and endothelial dysfunction.

Conclusions:

  • Endothelial dysfunction is a significant factor in severe COVID-19.
  • Understanding this pathophysiology can improve patient management strategies.
  • Further research is ongoing to validate these findings.