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Two patients, two viruses and multiple sites of injury in the kidney

Rezzan Eren Sadioglu1, Sahin Eyupoglu2, Saba Kiremitci3

  • 1Department of Nephrology, Ankara University School of Medicine, Talatpasa Bulvari No: 82, 06510, Altindag, Ankara, Türkiye. rezzanerensadioglu@gmail.com.

Journal of Nephrology
|August 28, 2020
PubMed

Insights

Viral nephropathies, kidney injuries caused by viruses, require renal biopsy for diagnosis. This study highlights successful treatments for Hantavirus and Human Immunodeficiency Virus (HIV)-associated nephropathies.

Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • Viral nephropathy involves kidney damage from direct viral infection or immune responses.
  • Establishing a direct link between viral infection and kidney disease can be challenging.
  • Viruses like Hepatitis B/C, HIV, Hantavirus, CMV, and Coronaviruses are known to impact renal health.

Observation:

  • Two patients presented with acute kidney injury and thrombocytopenia.
  • Renal biopsies revealed kidney damage affecting multiple renal compartments.
  • The causative viruses identified were Hantavirus and Human Immunodeficiency Virus (HIV).

Findings:

  • Hantavirus nephropathy was managed with supportive care.
  • HIV-associated nephropathy (HIVAN) treatment included antiretroviral therapy, eculizumab, and supportive measures.
  • Both treatment strategies led to successful patient outcomes.

Implications:

  • Renal biopsy is crucial for diagnosing viral nephropathies.
  • Tailored treatment approaches, including antivirals and immunomodulators, are effective.
  • Understanding viral mechanisms in kidney injury informs therapeutic strategies.
Keywords:
Acute kidney injuryHIVANHantavirusThrombotic microangiopathyViral nephropathy

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