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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis in patients with psoriasis: A systematic review and meta-analysis
Xinze Zhang1, Hongqiu Gu2, Shang Xie3
1Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Objective:
The present study aimed to summarize and update the evidence regarding the association between periodontitis and psoriasis.
Methods:
The present systematic review was conducted under the guidelines of Transparent Reporting of Systematic Reviews and Meta-Analyses (PRISMA) and was recorded in the PROSPERO database, under registration number CRD42017063799. Three databases (MEDLINE, Embase, and Cochrane Library) were searched up to March 2020. Case-control or cohort studies assessing the association between periodontitis and psoriasis were identified. Quantitative synthesis was conducted with meta-analysis.
Results:
A total of 13 studies (11 case-control and two cohort studies) assessing the association between periodontitis and psoriasis were included. Of these 13 articles, 9 showed the prevalence of periodontitis or psoriasis. Therefore, meta-analyses were conducted with data retrieved from the nine studies included. Pooled effect estimate for nine studies showed that patients with periodontitis associated with a higher risk of psoriasis with a pooled OR of 2.87 (95% CI, 1.75-4.69).
Conclusions:
This systematic review demonstrated a positive association between periodontitis and psoriasis; however, a causal relationship cannot be established. Due to the weak evidence, caution should be taken when interpreting the results regarding periodontal parameters. Well-designed prospective studies are necessary to evaluate interactions between both diseases.
