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Atopic dermatitis and bone health: a systematic review
I M Mukovozov1, D E Morra2,3, D Giustini4
1Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
Summary
Atopic dermatitis (AD) is linked to poorer bone health, including lower bone mineral density and increased fracture risk. Further research is needed to confirm this association and explore underlying causes.
Area of Science:
- Dermatology
- Bone Metabolism
- Systemic Inflammation
Background:
- Atopic dermatitis (AD) involves systemic inflammation.
- Systemic corticosteroid use in AD can negatively impact bone health.
- The relationship between AD and bone health requires further investigation.
Purpose of the Study:
- To systematically review the association between atopic dermatitis (AD) and bone mineral density (BMD).
- To investigate the link between AD and osteoporosis.
- To examine the relationship between AD and fracture risk.
Main Methods:
- Systematic review of studies from Web of Science, Cochrane, MEDLINE, and Embase.
- Duplicate screening, data extraction, and quality appraisal using established checklists.
- Inclusion of twelve cross-sectional and three cohort studies.
Main Results:
- Cross-sectional studies indicated AD is associated with decreased BMD and increased fractures.
- AD was linked to a higher prevalence of osteoporosis in both cross-sectional and cohort studies.
- A large cohort study found AD increased hip, spine, and wrist fracture risk, with severity correlating to risk.
Conclusions:
- Evidence suggests a potential association between atopic dermatitis and compromised bone health.
- Further research is necessary to elucidate mechanisms and develop interventions for bone health in AD patients.
- Clarifying the AD-bone health link is crucial for patient management.
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