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A multifunctional electrowritten bi-layered scaffold for guided bone regeneration.

Meifei Lian1, Yu Han2, Binbin Sun2

  • 1Department of Prosthodontics, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Acta Biomaterialia
|August 28, 2020
PubMed
Summary

This study developed a novel bi-layered scaffold for guided bone regeneration (GBR) that enhances bone growth and fights infection. The new scaffold shows promise for treating maxillofacial bone defects.

Keywords:
Bi-layered scaffoldCopperElectrospinningElectrowritingGuided bone regenerationMulti-functions

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Guided bone regeneration (GBR) is crucial for treating maxillofacial bone defects.
  • Current GBR membranes have limitations in bone regeneration and antibacterial activity.
  • Bi-layered scaffolds offer potential for improved GBR outcomes.

Purpose of the Study:

  • To design and fabricate a multifunctional bi-layered GBR scaffold.
  • To incorporate copper-loaded mesoporous silica nanoparticles (Cu@MSNs) for enhanced properties.
  • To evaluate the osteogenic and antibacterial potential of the novel scaffold.

Main Methods:

  • Fabrication of a bi-layered scaffold using solution electrospinning writing (SEW) and solution electrospinning (SES).
  • Incorporation of Cu@MSNs into a poly(lactic-co-glycolic acid)/gelatin (PLGA/Gel) matrix.
  • In vitro biological assays and in vivo studies using a rat periodontal defect model.

Main Results:

  • The scaffold exhibited a loose SEW layer for bone ingrowth and a dense SES layer for protection.
  • The composite scaffold demonstrated enhanced mechanical properties and a coordinated degradation profile.
  • In vitro tests showed favorable osteogenic and antibacterial activities; in vivo studies confirmed promising bone regeneration.

Conclusions:

  • The developed electrowritten, Cu@MSNs-incorporated bi-layered scaffold possesses hierarchical architecture.
  • The scaffold exhibits concurrent osteogenic and antibacterial functions, crucial for GBR.
  • This multifunctional scaffold holds significant potential for clinical application in guided bone regeneration.