Soluble intercellular cell adhesion molecule-1 in lung cancer: A meta-analysis

Area of Science:

• Oncology
• Biomarker Research
• Molecular Diagnostics

Background:

• Inconsistent findings exist regarding the prognostic and diagnostic value of soluble intercellular cell adhesion molecule-1 (sICAM-1) in lung cancer.
• This study systematically evaluates serum sICAM-1 as a potential biomarker in lung cancer patients.

Purpose of the Study:

• To investigate the diagnostic and prognostic significance of serum sICAM-1 in lung cancer.
• To explore the association between serum sICAM-1 levels and lung cancer staging and patient prognosis.

Main Methods:

• A systematic literature search was conducted across multiple databases (Wanfang, CNKI, PubMed, Embase) up to June 15, 2019.
• Meta-analysis techniques, including standard mean difference (SMD) and hazard ratio (HR), were used to analyze effect sizes.

Main Results:

• Serum sICAM-1 concentrations were significantly higher in lung cancer patients compared to healthy and benign lung disease controls.
• Elevated sICAM-1 levels were associated with advanced cancer stages (III/IV), lymph node metastasis, and distant metastasis.
• Higher serum sICAM-1 levels correlated with poorer progression-free survival and overall survival.

Conclusions:

• Serum sICAM-1 shows potential as a diagnostic marker for lung cancer.
• Serum sICAM-1 can aid in predicting lung cancer staging and is negatively correlated with patient prognosis.