Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

398
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
398
Depression: Overview01:18

Depression: Overview

629
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
629
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

327
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
327
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

134
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
134
Stress and Mental Health01:30

Stress and Mental Health

387
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
387
Long-term Depression01:03

Long-term Depression

2.9K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing Camouflaging in Adolescence: Psychometric Evaluation of the German Camouflaging Autistic Traits Questionnaire (CAT-Q/DE).

Journal of autism and developmental disorders·2026
Same author

Implementation and evaluation of family-based interventions within the Germany-wide Children of Mentally Ill Parents-network: study protocol for three prospective, rater-blinded, cluster-randomized controlled multicenter trials.

Frontiers in psychiatry·2026
Same author

Prevalence of avoidant/restrictive food intake disorder in children and adolescents with rare diseases.

Orphanet journal of rare diseases·2026
Same author

The Family Stress Model in families of children with rare diseases: a cross-sectional multilevel path analysis for understanding family dynamics.

Frontiers in public health·2025
Same author

Gender-specific insights on parenting children with rare diseases through multiple mediation analyses within the double ABCX model.

Research in developmental disabilities·2025
Same author

Development and optimization of an integrated exercise and nutrition program for ovarian cancer patients: Phase I of the BENITA multi-center study.

Gynecologic oncology·2025

Related Experiment Video

Updated: Dec 10, 2025

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

738

Does symptom severity matter in stepped and collaborative care for depression?

Birgit Watzke1, Daniela Heddaeus2, Maya Steinmann2

  • 1Clinical Psychology and Psychotherapy Research, Institute of Psychology, University of Zurich, Binzmühlestrasse 14/16, CH-8050 Zurich, Switzerland.

Journal of Affective Disorders
|August 28, 2020
PubMed
Summary

The stepped and collaborative care model (SCM) effectively treats both mild-moderate and severe depression in primary care patients. Treatment utilization patterns may explain observed differences in effectiveness between depression severity groups.

Keywords:
Collaborative careDepressionOutcomeSeverity subgroupsStepped careTreatment utilization

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.1K
Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:36

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

77

Related Experiment Videos

Last Updated: Dec 10, 2025

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

738
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.1K
Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:36

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

77

Area of Science:

  • Clinical Psychology
  • Psychiatry
  • Primary Care Medicine

Background:

  • Investigated the comparative effectiveness of a stepped and collaborative care model (SCM) against treatment as usual (TAU).
  • Focused on primary care patients experiencing varying degrees of depression severity.
  • Examined differential treatment utilization across patient subgroups.

Purpose of the Study:

  • To determine the differential effectiveness of SCM versus TAU for patients with mild-moderate depression (MMD) and severe depression (SD).
  • To explore whether specific patient subgroups received distinct evidence-based treatments within the SCM framework.

Main Methods:

  • Conducted subgroup analyses of a randomized controlled trial (RCT) using a multiple linear mixed model.
  • Factors included group (SCM vs. TAU) and depression severity (MMD vs. SD), with interaction terms.
  • Primary outcome was measured by the Patient Health Questionnaire-9 (PHQ-9); treatment utilization was analyzed descriptively.

Main Results:

  • Initial analysis revealed a significant interaction between group and severity, with SCM showing greater symptom reduction in MMD patients compared to TAU.
  • Effect sizes for symptom reduction were significant for MMD (d=0.64) but not for SD (d=0.27) in the initial analysis.
  • Sensitivity analyses indicated significant effects for both severity groups, with slightly larger effect sizes for MMD, and greater utilization of depression-specific treatments in MMD patients under SCM.

Conclusions:

  • The stepped and collaborative care model (SCM) demonstrates effectiveness for both mild-moderate and severe depression.
  • Differences in treatment utilization patterns may contribute to the observed higher effectiveness of SCM in mild-moderate depression.
  • Missing data, particularly in severely depressed patients within the SCM group, influenced results, necessitating careful consideration of imputation strategies.