Related Experiment Video

Updated: Dec 10, 2025

Use of Micropipette-Guided Drug Administration as an Alternative Method to Oral Gavage in Rodent Models
02:44

Use of Micropipette-Guided Drug Administration as an Alternative Method to Oral Gavage in Rodent Models

Published on: July 26, 2024

2.4K

A Novel Oral Syringe for Dosing and Administration of Multiparticulate Formulations: Acceptability Study in Preschool

Justyna Katarzyna Hofmanová1, Joanne Bennett2, Alastair Coupe2

  • 1School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, UK.

Pharmaceutics
|August 29, 2020
PubMed

Insights

A novel oral syringe effectively dispenses multiparticulate formulations (MPs) for children. This device allows flexible dosing of MPs, improving medication administration for pediatric patients.

Area of Science:

  • Pediatric pharmacology
  • Drug delivery systems
  • Formulation science

Background:

  • Multiparticulate formulations (MPs) are increasingly popular pediatric dosage forms due to ease of swallowing.
  • Current administration methods for MPs, such as unit doses, limit flexible dosing potential.
  • A standardized pediatric device could optimize the administration of MPs.

Purpose of the Study:

  • To evaluate a novel oral syringe designed for dispensing and administering multiparticulate formulations (MPs) to children.
  • To assess the swallowability and acceptability of different dose volumes administered via the novel oral syringe.
  • To determine if a drink of choice improves acceptability compared to water.

Main Methods:

  • Forty children aged 4-12 years participated in the study.
  • Placebo MPs were administered in 0.5, 1.2, and 2.0 mL doses using the novel oral syringe.
  • Doses were given with either spring water or a drink of choice.
  • Swallowability and willingness to take the dose daily were recorded.

Main Results:

  • Swallowability decreased with increasing dose volume; 87.5% swallowed the smallest dose (0.5 mL).
  • Willingness to take the smallest dose daily was 69.4%.
  • Acceptability and willingness to take larger doses (1.2 and 2.0 mL) were lower, and a drink of choice did not improve swallowability.

Conclusions:

  • The novel oral syringe is a suitable device for flexible dispensing and direct administration of low-volume, neutral-tasting MPs in children aged 4-12.
  • The device shows promise for improving pediatric medication administration, particularly for smaller doses.
  • Further research may explore optimizing administration for larger MP volumes.

Keywords:
acceptabilityadministration devicemouthfeelmultiparticulatesoral syringepaediatric formulation

More Related Videos

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

8.0K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.3K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
148
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
147
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
558
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
172
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
102
Dosage Interval and Administration Route: Determination Methods01:19

Dosage Interval and Administration Route: Determination Methods

A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to...
113