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Kawasaki disease epidemic: pitfalls
Romina Gallizzi1, Giovanni Corsello2, Giovanni Battista Pajno3
1Department of Human Pathology of Adulthood and Childhood Gaetano Barresi, Gaetano Martino University Hospital, UOC Pediatria, University of Messina, Via Consolare Valeria, 98125, Messina, Italy. rgallizzi@unime.it.
Italian Journal of Pediatrics
|August 29, 2020
Summary
A new hyperinflammatory syndrome in children, potentially linked to SARS-CoV-2, shares features with Kawasaki disease (KD). This commentary explores the possible association between SARS-CoV-2 infection and KD in susceptible individuals.
Area of Science:
- Pediatric infectious diseases
- Immunology
- Cardiology
Background:
- Recent reports indicate a novel hyperinflammatory response in children post-SARS-CoV-2 infection.
- This pediatric condition exhibits clinical similarities to Kawasaki disease (KD).
Purpose of the Study:
- To discuss the potential association between SARS-CoV-2 and Kawasaki disease (KD).
Main Methods:
- This is a commentary, not an experimental study.
- Review of recent clinical reports and existing literature on KD etiology.
Main Results:
- A possible link between SARS-CoV-2 and KD-like symptoms in children is proposed.
- SARS-CoV-2 may act as a trigger for an exaggerated inflammatory response in genetically susceptible children.
Conclusions:
- The SARS-CoV-2 virus could potentially induce Kawasaki disease (KD) or KD-like symptoms in predisposed pediatric patients.
- Further research is needed to confirm the causal relationship and understand the underlying mechanisms.
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