[Pancreatic endocrine function of patients with nonspecific ulcerative colitis]

Pancreatic endocrine function was investigated in 43 patients with nonspecific ulcerative colitis by studying the blood concentrations of insulin, C-peptide and glucagon using a radioimmunoassay. In such patients the level of C-peptide was on a decrease, that of glucagon--on an increase. The level of insulin in nonspecific ulcerative colitis showed a tendency to increase. These alterations were closely connected with pancreatic excretory function. The most profound changes were noted in patients with markedly lowered pancreatic excretory function.