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Updated: Aug 2, 2026
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
Opportunities for the federal government to advance necrotizing enterocolitis research
Samir K Gadepalli1, Jennifer Canvasser2, Misty Good3
1Division of Pediatric Surgery, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA. samirg@med.umich.edu.
Background:
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in the neonatal ICU with minimal progress in the research.
Methods:
Federal webpages were queried to look for funding opportunity announcements (FOAs) and to develop lists of funded projects on NEC to identify gaps in NEC-related research topics.
Results:
Over the past 30 years, the National Institutes of Health (NIH) issued two FOAs to stimulate research on NEC with $4.1 million set aside for the first year of respective funding. We identified 23 recently funded studies of which 18 were research projects, 4 training grants, and 1 conference grant support. Only one grant focused on parent and family engagement in the NICU.
Conclusion:
There are significant research gaps that can be addressed with adequate funding from the federal government on the prevention and treatment of NEC.
