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Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore

Lorine Giffard-Quillon1, Helene Desmurs-Clavel1,2, Claire Grange1,3

  • 1GEMMAT Groupe d'Etude Multidisciplinaire en Maladies Thrombotiques, Lyon, France.

Thrombosis Journal
|August 29, 2020
PubMed

Rivaroxaban has the most available data to support the use of prothrombin complex concentrates (PCC) as a reversal agent. However, PCC might increase the incidence of thrombotic events by shifting the haemostatic balance towards hypercoagulability. We assessed the in vitro efficacy and safety of three 4-factor PCCs for reversing rivaroxaban anticoagulant effect. Our in vitro finding indicates that 4-factor PCCs at the dose of 25 U.kg- 1 may be sufficient to reverse rivaroxaban anticoagulant effect.

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